AbstractIn this paper, it aims to build the relationship of statically electric interaction between the surface charge of a particle drug and cellular uptake. The statically electric theory is applied to study the change of wetting between the drug particle and the cell, a factor that enhanced uptake of cells induced by particle’s surface charge is introduced, then it is formulated according to Kelvin theory for dissolving of solid particle in liquid. It is found that the change of contact angle between the surface charged particle drug and the cell can be detected if the Zeta potential reaches to 6 mV in water like solution, an increase of about 11.1% for the uptake could be obtained for a polymer particle with molar mass