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2012 IEEE Second International Conference on Healthcare Informatics, Imaging and Systems Biology

DOI: 10.1109/hisb.2012.66

BioMed Central, BMC Systems Biology, Suppl 3(7), p. S8

DOI: 10.1186/1752-0509-7-s3-s8

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Intra-relation Reconstruction from Inter-relation: miRNA to Gene Expression

Journal article published in 2012 by Dokyoon Kim, Hyunjung Shin, Je-Gun Joung ORCID, Su-Yeon Lee, Ju Han Kim
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

BACKGROUND: In computational biology, a novel knowledge has been obtained mostly by identifying 'intra-relation,' the relation between entities on a specific biological level such as from gene expression or from microRNA (miRNA) and many such researches have been successful. However, intra-relations are not fully explaining complex cancer mechanisms because the inter-relation information between different levels of genomic data is missing, e.g. miRNA and its target genes. The 'inter-relation' between different levels of genomic data can be constructed from biological experimental data as well as genomic knowledge.