Published in
American Chemical Society, Organic Letters, 3(17), p. 656-659, 2015
DOI: 10.1021/ol503646c
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Arthpyrones A–C, Pyridone Alkaloids from a Sponge-Derived Fungus Arthrinium arundinis ZSDS1-F3
,
Xuefeng Zhou,
Xiuping Lin,
Bin Yang,
Shengrong Liao ,
Juan Liu,
Zhengchao Tu,
Yonghong Liu
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- Must obtain written permission from Editor
- Must not violate ACS ethical Guidelines
Abstract
Three new 4-hydroxy-2-pyridone alkaloids, arthpyrones A-C (1-3), were isolated from the sponge-derived fungus Arthrinium arundinis ZSDS1-F3. Their structures were elucidated on the basis of spectroscopic analysis, CD spectra, quantum chemical calculation, and X-ray single-crystal diffraction analysis. Compounds 1 and 2 possessed a 2-pyridone core featured with a decalin moiety linked via a carboxide bridge bearing a novel oxabicyclo[3.3.1]nonane ring system rarely discovered in nature. A possible biosynthetic pathway for them was proposed.