American Association for the Advancement of Science, Science Translational Medicine, 204(5), 2013
DOI: 10.1126/scitranslmed.3006386
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Mills et al. recently used mathematical modeling to show that community-wide isoniazid preventative therapy may lead to a long-term increase in resistance at the population level. Although community-wide isoniazid preventive therapy may be useful in preventing tuberculosis (TB) in low-TB/HIV settings, isoniazid resistance is especially of concern in high TB/HIV populations.