Elsevier, Journal of Fluorine Chemistry, (167), p. 172-178, 2014
DOI: 10.1016/j.jfluchem.2014.05.009
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Oxy-trifluoromethylation of di-substituted styrenes and dienes was achieved by using Cu/Togni's reagent system. Not only gem-di-substituted styrenes, but also a beta-methylstyrene derivative were transformed to the corresponding oxy-trifluoromethylation products. 1,4-Addition products were obtained selectively in the reaction of mono-substituted dienes. These reactions provide a new approach for the synthesis of beta-trifluoromethyl styrene derivatives. (C) 2014 The Authors. Published by Elsevier B.V.