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Elsevier, Journal of Fluorine Chemistry, (167), p. 172-178, 2014

DOI: 10.1016/j.jfluchem.2014.05.009

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Oxy-trifluoromethylation of alkenes and its application to the synthesis of β-trifluoromethylstyrene derivatives

Journal article published in 2014 by Hiromichi Egami, Ryo Shimizu, Yoshihiko Usui, Mikiko Sodeoka ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Oxy-trifluoromethylation of di-substituted styrenes and dienes was achieved by using Cu/Togni's reagent system. Not only gem-di-substituted styrenes, but also a beta-methylstyrene derivative were transformed to the corresponding oxy-trifluoromethylation products. 1,4-Addition products were obtained selectively in the reaction of mono-substituted dienes. These reactions provide a new approach for the synthesis of beta-trifluoromethyl styrene derivatives. (C) 2014 The Authors. Published by Elsevier B.V.