Published in
Elsevier, Tetrahedron Letters, 44(41), p. 8577-8580
DOI: 10.1016/s0040-4039(00)01490-8
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Conjugate intra- and intermolecular addition mediated by methoxide anion on polymeric support
Journal article published in 2000 by
Cristiana Fava,
Roberta Galeazzi 
,
Eugenia Maria Gonzalez-Rosende,
Mario Orena
,
Eugenia Maria Gonzalez-Rosende,
Mario Orena
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Abstract
By treatment with methoxide anion on polymeric support (IRA 900), chiral β-oxo or β-sulphonylamides 2 bearing an α,β-unsaturated ester gave 3,4-disubstituted pyrrolidin-2-ones 3 as easily separable diastereomeric mixtures in good yield and moderate-to-good stereoselection. The polymeric reagent was also effective in promoting both intermolecular conjugate addition and alkylation reactions.