Published in
Elsevier, Bioorganic and Medicinal Chemistry, 1(8), p. 135-143
DOI: 10.1016/s0968-0896(99)00267-9
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Synthesis and evaluation as glycosidase inhibitors of 2,5-imino-D-glucitol and 1,5-imino-D-mannitol related derivatives
Journal article published in 2000 by
Isabelle McCort 
,
Annie Duréault,
Sébastien Fort ,
Jean-Claude Depezay
,
Annie Duréault,
Sébastien Fort ,
Jean-Claude Depezay
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Abstract
Selectively functionalized 2,5-imino-D-glucitol and 1,5-imino-D-mannitol derivatives were synthesized and tested as precursors of hydrolytically resistant pseudo-disaccharides. Among them N-acetyl-6-amino-6-deoxy-2,5-imino-D-glucitol (11) and N-acetyl-6-amino-6-deoxy-1,5-imino-D-mannitol (12) were found potent and specific inhibitors against beta-D-glucosidase and alpha-L-fucosidase, respectively.