Published in
Nucleosides and Nucleotides, 9-11(17), p. 1709-1716
DOI: 10.1080/07328319808004705
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Studies on Alternate Strand Triple Helix Formation by Oligodeoxyribonucleotides Containing A 3′-3′ Phosphodiester Bond
Journal article published in 1998 by
L. De Napoli,
A. Galeone 
,
L. Mayol ,
A. Messere,
D. Montesarchio,
A. Pepe,
G. Piccialli
,
L. Mayol ,
A. Messere,
D. Montesarchio,
A. Pepe,
G. Piccialli
Abstract
ODNs containing a 3′-3′ phosphodiester linkage as inversion of polarity motif have been shown to cooperatively bind to 5′-(purine)m(pyrimidine)n-3′ type duplexes by specific alternate strand recognition of the adjacent oligopurine domains. An NMR study has been undertaken to investigate the role of the 3′-3′ linked nucleosides and their nearest neighbours in the stabilization of the triple helical complexes.