Combinatorial Synthesis of Peptidomimetics Using Digital Microfluidics
Journal article published in 2012 by
Mais J. Jebrail,
Naila Assem,
Jared M. Mudrik,
Michael D. M. Dryden,
Kaixian Lin,
Andrei K. Yudin,
Aaron R. Wheeler
This paper is made freely available by the publisher.
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Abstract
A microfluidic technique for combinatorial chemical synthesis of peptidomimetics has been developed. The new method is fast, automated and includes an integrated magnetic separation of inorganic catalysts from reaction products. This proof-of-concept study should lead to methods for generating libraries of compounds suitable for screening for bioactivity.