PDGF is a growth factor and is extensively involved in multi-dimensional cellular dynamics. It switches on a plethora of molecules other than its classical pathway. It is engaged in various transitions of development however if the unleashed potentials lead astray it brings forth tumorigenesis. Conventionally, it has been assumed that the components of this signaling pathway show fidelity and act with a high degree of autonomy. However, as illustrated by the PDGF signal transduction, reinterpretation of recent data suggests that machinery is often shared between multiple pathways and other components crosstalk to each other through multiple mechanisms. There is a very indiscriminate line that demarcates between normal division and neoplasia. A number of unidentified proteins might be instrumental to this transition. The signal perpetuation is a remarkable portfolio of tumor progression.