Dissemin is shutting down on January 1st, 2025

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American Society of Hematology, Blood, 2(125), p. 212-213, 2015

DOI: 10.1182/blood-2014-10-606624

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TET2 loss, a rescue of JAK2V617F HSCs

Journal article published in 2015 by William Vainchenker ORCID, Isabelle Plo
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

In this issue of Blood, Chen et al1 and Kameda et al2 demonstrate that Tet2 loss has 2 effects in Jak2V617F mice: it increases both the severity of the myeloproliferative disorders and the self-renewal properties of the Jak2V617F hematopoietic stem cells (HSCs).