American Association for the Advancement of Science, Science, 5967(327), p. 883-886, 2010
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Pinpointing Genetic Selection The human genome contains hundreds of regions with evidence of recent positive natural selection, yet, for all but a handful of cases, the underlying advantageous mutation remains unknown. Current methods to detect the signal of selection often results in the identification of a broad genomic region containing many candidate regions that vary among individuals. By combining existing statistical methods, Grossman et al. (p. 883 , published online 7 January) developed a method, termed Composite of Multiple Signals, which can increase the ability to pinpoint the specific variant under selection. Several candidate regions under selection in human populations were identified.