Published in
Wiley, ChemBioChem, 5(14), p. 564-567, 2013
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- [www.ncbi.nlm.nih.gov] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
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An Enzymatic Route to Selenazolines
Journal article published in 2013 by
Jesko Koehnke,
Falk Morawitz,
Andrew F. Bent,
Wael E. Houssen 
,
Sally L. Shirran,
Matthew A. Fuszard,
Iain A. Smellie,
Catherine H. Botting,
Margaret C. M. Smith,
Marcel Jaspars,
James H. Naismith
,
Sally L. Shirran,
Matthew A. Fuszard,
Iain A. Smellie,
Catherine H. Botting,
Margaret C. M. Smith,
Marcel Jaspars,
James H. Naismith
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Abstract
Ringing the changes: Selenazolines have applications in medicinal chemistry, but their synthesis is challenging. We report a new convenient and less toxic route to these heterocycles that starts from commercially available selenocysteine. The new route depends on a heterocyclase enzyme that creates oxazolines and thiazolines from serines/threonines and cysteines.