Although online setup correction is beneficial during high-dose radiotherapy, little is known about the attitudes and concerns of stakeholders directly involved in this process. Therefore, the purpose of this research was to explore radiation oncologists' and therapists' insights on changes in workload, procedures, and professional practice resulting from involvement in therapist-autonomous online setup correction for patients receiving radiotherapy for prostate cancer.This was a single-center study with a qualitative design. All 10 radiation oncologists and 20 therapists involved in the online-autonomous process for prostate radiotherapy were approached for participation. Two specifically designed questionnaires were developed (one for therapists and one for oncologists) using a standard interview-to-pilot process. These were distributed to the participants both by hand and by e-mail. Content analysis methods and descriptive statistics were used to summarize the qualitative responses.Twenty-eight responses to the questionnaire were received. According to the results, the online-autonomous process was considered efficient when left solely in the hands of therapists (27 of 28 responses). Participant confidence with the process was influenced by communication (8/8), education (23/28), and documentation (20/20). Stakeholder perceptions indicated that the process was implemented exclusively to improve patient outcomes (28/28). The respondents experienced no professional resentment or resistance to change (20/20). The assumption of responsibility for online setup correction improved the therapists' perceptions of their role and themselves as professionals.Despite limited generalizability, this study confirms that within a well-established process, radiation oncologists are willing to cede responsibility for autonomous image approval and setup correction to therapists. Despite increases in professional accountability, radiation therapists are prepared to accept that responsibility for the benefit of their patients.