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De Gruyter, Zeitschrift für Naturforschung B, 3(68), p. 229-238, 2013

DOI: 10.5560/znb.2013-2297

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Synthesis and anti-HIV Activity of New Fused Chromene Derivatives Derived from 2-Amino-4-(1-naphthyl)-5-oxo-4H,5H-pyrano[3,2-c]chromene-3-carbonitrile

Journal article published in 2013 by Najim A. Al-Masoudi, Hamid H. Mohammed, Aws M. Hamdy, Omer A. Akrawi, Nadi Eleya, Anke Spannenberg, Christophe Pannecouque, Peter Langer
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

A new series of pyrano-chromene and pyrimido pyrano-chromene derivatives were synthesized starting from 2-amino-4-(1-naphthyl)-5-oxo-4H,5H-pyrano[3,2-c]chromene-3-carbonitrile (6). The structures of the synthesized compounds were elucidated by spectral data. Compounds 6-11, 13-15 and 18 have been selected for an inhibitory activity screening against HIV-1 and HIV-2 in MT-4 cells.