Published in

Instituto Oswaldo Cruz, Ministério da Saúde, Memórias do Instituto Oswaldo Cruz., suppl 1(100), p. 25-27, 2005

DOI: 10.1590/s0074-02762005000900006

Links

Tools

Export citation

Search in Google Scholar

Nitric oxide synthase activity and endogenous inhibitors in rats recovered from allergic encephalomyelitis

Journal article published in 2005 by Teixeira Sa, S. A. Teixeira, Aa A. Varriano, Dias Aa, A. A. Dias, R. Martins Porto, Rm M. Porto, Mn N. Muscará ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Question mark in circle
Preprint: policy unknown
Upload
Question mark in circle
Postprint: policy unknown
Upload
Question mark in circle
Published version: policy unknown
Upload
Policy details
Data provided by SHERPA/RoMEO

Abstract

We have previously reported that in comparison with normal rats, the presence of experimental allergic encephalomyelitis (EAE) leads to decreased endogenous inhibitory activity (EIA) of Ca2+-dependent nitric oxide synthase (NOS) in both brain and serum, and increased expression of protein 3-nitrotyrosine (NT) in brain. In this work we show that animals recovered from the clinical signs of EAE are not different from controls in terms of either brain NOS activity, EIA of NOS, or NT expression. These results suggest that parallel to the reversal of the disease symptoms, a normalization of the production of nitric oxide and related species occurs.