Links
- ORCID
- Crossref | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [www.researchgate.net] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [europepmc.org] | PDF
Tools
Effects of Cytotoxic T Lymphocytes (CTL) Directed against a Single Simian Immunodeficiency Virus (SIV) Gag CTL Epitope on the Course of SIVmac239 Infection
Journal article published in 2002 by
Todd M. Allen,
Peicheng Jing,
Briana Calore,
Helen Horton,
David H. O'Connor 
,
Tomas Hanke,
Marian Piekarczyk,
Richard Ruddersdorf,
Bianca R. Mothé,
Carol Emerson,
Nancy Wilson,
Jeffrey D. Lifson,
Igor M. Belyakov,
Jay A. Berzofsky,
Chenxi Wang
and other authors.
,
Tomas Hanke,
Marian Piekarczyk,
Richard Ruddersdorf,
Bianca R. Mothé,
Carol Emerson,
Nancy Wilson,
Jeffrey D. Lifson,
Igor M. Belyakov,
Jay A. Berzofsky,
Chenxi Wang
and other authors.
Abstract
Vaccine-induced cytotoxic T lymphocytes (CTL) have been implicated in the control of virus replication in simian immunodeficiency virus (SIV)-challenged and simian-human immunodeficiency virus-challenged macaques. Therefore, we wanted to test the impact that vaccine-induced CTL responses against an immunodominant Gag epitope might have in the absence of other immune responses. By themselves, these strong CTL responses failed to control SIVmac239 replication.