Acute disabilities always need different types of assistive devices in their daily life. Usually, each of these devices is designed for only one particular usage. Because of this, an acute disable may have to use a joystick to manipulate his wheelchair, used a mouse to control computer, or used a keyboard to control movement of mechanical arm. Thus no consideration of interrelations among these tools was discussed. In 1990, the technical working committee 173 (TC-173/sc-1/wg-7) of ISO (International Organization for Standardization) using serial interface protocol (ISO 7176-7) to integrate all types of assistive tools for the disabilities. At the same time, the European Common Commission funded the research for M3S interface (Multiple Masters Multiple Slave). It provides the disable a concrete integral control for his movement, working, environment control and communication. This is an integrated intelligent real time control capability protocol. It is a plug and play device interface. We design and develop a M3S protocol using TMS320F243 DSP chip. The system was tested for I/O control and it meets the equipments supported by the M3S working group. Thus, it would bring lots of comforts for the disable.