Recently, several metal oxide nanomaterials have been deposited on the surface of electrodes and investigated for the reduction/ oxidation and detection of some biological materials. Electrochemical Sensors with high surface area and porosity are important components in an irresistible wealth of systems for various applications. An electrochemical sensor for the sensitive determination of parabromophenol (PBP) was synthesized based on the nano-SiO2 film-modified electrode. Owing to the exceptional properties of nano-SiO2 such as successfully minimized transport limitations, huge surface area, strong adsorptive ability, subtle electronic properties and catalytic ability, the electrochemical oxidation signal of PBP significantly increases at the nano- SiO2/GC electrochemical sensor, suggesting that nano-SiO2 film exhibits obvious enhancement effect to the determination of PBP. Based on this, a sensitive electrochemical method was developed for the determination of PBP.