Here we outline serious diseases of wildlife, food and fiber animals, and non-human primates that cause damaging economic effects on producers all over the world. While some zoonotic viruses that occasionally cause serious disease and death in humans are mentioned, the positive sense RNA viruses generally cause economic damage that can have serious societal implications for humans. Finally, honorable mention is given to yellow fever virus, a success of vaccine development efforts. This virus once caused similar serious effects (in humans) during the construction of the Panama Canal, but has been relegated to a footnote in textbooks because of a cheap and effective vaccine