Prediction of HIV Drug Resistance Based on Virologic, Immunologic, Clinical, and/or Adherence Criteria in the Stratall ANRS 12110/ESTHER Trial in Cameroon

Tongo, M.; Tadewa, V.; Voundi, H. D.; Tang, S.; Tchuangue, E.; Tchuenko, S.; Yakan, D.; Tigougmo, M.; Wankam, D.; Zobo, I.; Tadena, M.; Tchouamou, L.; Zambou, B.; Tchinda, Y.; Boullé, Charlotte; Kouanfack, Charles; Biwole-Sida, M.; Laborde-Balen, Gabrièle; Koulla-Shiro, S.; Bourgeois, A.; Aghokeng, Avelin Fobang; Laborde-Balen, Gabriele; Edoul, M. G.; Boyer, Sylvie; Marcellin, F.; Moatti, J.-P.; Carrieri, Maria Patrizia; Abe, C.; Abega, S.-C.; Bonono, C.-R.; Mimcheu, H.; Ngo Yebga, S.; Kazé, Serge; Paul Bile, C.; Abada, S.; Abanda, T.; Kaze, Serge; Spire, Bruno; Baga, J.; Bilobi Fouda, P.; Etong Mve, P.; Mben, Jean-Marc; Fetse Tama, G.; Kemo, H.; Ongodo, A.; Dontsop, Marlise; Ambani, A.; Atangana, M.; Biaback, J.-C.; Kennedy, M.; Kibedou, H.; Kounga, F.; Maguip Abanda, M.; Mamang, E.; Peeters, Martine; Mikone, A.; Assandje, J.; Ebana, S.; Ebo'o, D.; Etoundi, D.; Mpoudi-Ngolé, Eitel; Ngama, G.; Mpoudi-Ngole, Eitel; Mbarga Ango, P.; Delaporte, Eric; Mbezele, J.; Mbong, G.; Moung, C.; Ekotto, N.; Laurent, Christian; Nguemba Balla, G.; Ottou, G.; Beyala, R.; Ebene, B.; Effemba, C.; Eyebe, F.; Hadjaratou, M.-M.; Mbarga, T.; Metou, M.; Ndam, M.; Ngoa, B.; Ngock, E. B.; Obam, N.; Abomo, A. M.; Angoula, G.; Ekassi, E.; Lentchou, J. J.; Mvilongo, I.; Ngapou, J.; Ntokombo, F.; Ondoua, V.; Palawo, R.; Sebe, S.; Sinou, E.; Akono, B.; Ambani, A. L.; Bilock, L.; Bilo'o, R.; Boombhi, J.; Fouda, F. X.; Guitonga, M.; Mad'aa, R.; Metou'ou, D. R.; Mgbih, S.; Noah, A.; Ambassa Elime, G.; Bonongnaba, A. A.; Foaleng, E.; Heles, R. M.; Messina, R.; Nana Ndankou, O.; Ngono, S. A.; Ngono Menounga, D.; Sil, S. S.; Abomo, R.; Ambomo, J.; Beyomo, C.; Eloundou, P.; Ewole, C.; Fokom, J.; Mvoto, M.; Ngadena, M.; Nyolo, R.; Onana, C.; Oyie, A.; Antyimi, P.; Bella Mbatonga, S.; Bikomo, M.; Molo Bodo, Y.; Ndi Ntang, S.; Ndoudoumou, P.; Ndzomo, L.; Ngolo, S. O.; Nkengue, M.; Stratall, Anrs Esther Study

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Oxford University Press, Clinical Infectious Diseases, 4(57), p. 604-607, 2013

DOI: 10.1093/cid/cit323

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Prediction of HIV Drug Resistance Based on Virologic, Immunologic, Clinical, and/or Adherence Criteria in the Stratall ANRS 12110/ESTHER Trial in Cameroon

Journal article published in 2013 by M. Tongo, V. Tadewa, H. D. Voundi, S. Tang, E. Tchuangue, S. Tchuenko, D. Yakan, M. Tigougmo, D. Wankam, I. Zobo, M. Tadena, L. Tchouamou, B. Zambou, Y. Tchinda, Charlotte Boullé and other authors.

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Abstract

Our study in Cameroonian rural district hospitals showed that the immunologic and clinical failure criteria had poor performance to identify HIV drug-resistance in a timely manner. Switching to second-line antiretroviral therapy after two consecutive viral loads ≥5000 copies/mL, as recommended by the WHO, appeared the most appropriate strategy.

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Prediction of HIV Drug Resistance Based on Virologic, Immunologic, Clinical, and/or Adherence Criteria in the Stratall ANRS 12110/ESTHER Trial in Cameroon

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