Published in
Nature Research, Nature Genetics, 9(40), p. 1056-1058, 2008
DOI: 10.1038/ng.209
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Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder.
,
Michael C. O’Donovan,
Manuel A. R. Ferreira,
Yan A. Meng,
Ian R. Jones,
Douglas M. Ruderfer ,
Lisa Jones,
Jinbo Fan,
George Kirov,
Roy H. Perlis,
Elaine K. Green,
Jordan W. Smoller,
Detelina Grozeva,
Jennifer Stone,
Ivan Nikolov
and other authors.
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Abstract
To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases and 6,209 controls and identified a region of strong association (rs10994336, P = 9.1 10-9) in ANK3 (ankyrin G). We also found further support for the previously reported CACNA1C (alpha 1C subunit of the L-type voltage-gated calcium channel; combined P = 7.0 10-8, rs1006737). Our results suggest that ion channelopathies may be involved in the pathogenesis of bipolar disorder. ; PUBLISHED