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Bentham Science Publishers, Letters in Drug Design & Discovery, 8(7), p. 610-617

DOI: 10.2174/157018010792062731

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Lithocholic Acid Derivative as a Model for Artificial Receptors: A Raman Study

Journal article published in 2010 by F. M. F. Roleira ORCID, E. J. Tavares da Silva ORCID, Rui A. Carvalho, M. P. M. Marques
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This paper is available in a repository.

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Abstract

Two lithocholic acid (LCA) derivatives — mono- and diesters (newly synthetised) — are studied for their main conformational preferences, by Raman spectroscopy coupled to theoretical (DFT) methods. Raman bands characteristic of each compound were assigned, allowing an accurate and rapid identification of this kind of systems. The conformational preferences of the LCA diester were related with its ability to function as a model for artificial receptors, displaying a tailored structural profile.