Till now, the developed centimeter-sized Ti-based bulk metallic glasses (BMGs) always consist of at least five elements. We report that Ti ₄₁ Zr ₂₅ Be ₂₈ Fe ₆ quaternary glassy alloy can be made up to 10 mm in diameter by water quenching, while only ϕ 8 mm fully glassy rod can be obtained by copper mould suction casting. This alloy possesses fewer constituent elements, wider supercooled liquid region and higher specific strength than other developed centimeter-sized Ti-based BMGs and has wide prospect for practical application. Our results also indicate that for Ti ₄₁ Zr ₂₅ Be ₂₈ Fe ₆ alloy which possesses relatively strong glass-forming ability, reducing the heterogeneous impurities in the melt is more effective to obtain fully glassy samples than increasing the cooling rate merely.