Published in

Taylor and Francis Group, OncoImmunology, 2(3), p. e27573

DOI: 10.4161/onci.27573

Links

Tools

Export citation

Search in Google Scholar

The short and sweet of T-cell therapy

Journal article published in 2014 by Madhusudhanan Sukumar, Luca Gattinoni ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Red circle
Preprint: archiving forbidden
Orange circle
Postprint: archiving restricted
Upload
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

Upon antigenic stimulation, naïve CD8(+) T cells divert their bioenergetic metabolism from oxidative phosphorylation to aerobic glycolysis. This drives CD8(+) T cells to differentiate into short-lived effectors, impairing the establishment of immunological memory. The pharmacological inhibition of glycolysis with 2-deoxyglucose enhances the generation of memory CD8(+) T cells and thus improves their immunotherapeutic potential against cancer.