The record of Mio-Pliocene continental sediments is very complete in the Granada Basin (southern Spain), and many fossiliferous localities have yielded material of Rodentia, Lipotyphla and Lagomorpha. The most diversified and numerous are rodents, more specifically the family Muridae. Seventeen murid species, belonging to eight genera (Castromys, Occitanomys, Stephanomys, Apodemus, Paraethomys, Castillomys, Micromys, and Muridae gen. et sp. indet.), have been identified. New data on these genera have been used to propose and corroborate some phylogenetic hypotheses. The studied localities range in age from middle Turolian to early Ruscinian, and the variation of the relative abundance of the faunas through time show a faunistic replacement between the middle-late Turolian transition and the late Turolian-early Ruscinian.