It is shown that a vertex-transitive graph of valency p+1, p a prime, admitting a transitive action of a {2,p}-group, has a non-identity semiregular automorphism. As a consequence, it is proved that a quartic vertex-transitive graph has a non-identity semiregular automorphism, thus giving a partial affirmative answer to the conjecture that all vertex-transitive graphs have such an automorphism and, more generally, that all 2-closed transitive permutation groups contain such an element (see [D. Marušič, On vertex symmetric digraphs, Discrete Math. 36 (1981) 69–81; P.J. Cameron (Ed.), Problems from the Fifteenth British Combinatorial Conference, Discrete Math. 167/168 (1997) 605–615]).