Published in

Wiley, Chemistry - A European Journal, 49(20), p. 16088-16092, 2014

DOI: 10.1002/chem.201405450

Links

Tools

Export citation

Search in Google Scholar

Near-IR Absorbing BODIPY Derivatives as Glutathione-Activated Photosensitizers for Selective Photodynamic Action

Journal article published in 2014 by Ilke Simsek Turan, Fatma Pir Cakmak, Deniz Cansen Yildirim, Rengul Cetin‐Atalay ORCID, Engin U. Akkaya ORCID
This paper is available in a repository.
This paper is available in a repository.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Orange circle
Postprint: archiving restricted
Upload
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

Enhanced spatiotemporal selectivity in photonic sensitization of dissolved molecular oxygen is an important target for improving the potential and the practical applications of photodynamic therapy. Considering the high intracellular glutathione concentrations within cancer cells, a series of BODIPY-based sensitizers that can generate cytotoxic singlet oxygen only after glutathione-mediated cleavage of the electron-sink module were designed and synthesized. Cell culture studies not only validate our design, but also suggest an additional role for the relatively hydrophobic quencher module in the internalization of the photosensitizer.