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BioMed Central, BMC Infectious Diseases, 1(14), 2014

DOI: 10.1186/1471-2334-14-96

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A prospective study of age trends of high-risk human papillomavirus infection in rural China

Journal article published in 2014 by Le-Ni Kang, Philip Edward Castle, Fang-Hui Zhao, Jose Jeronimo, Feng Chen, Pooja Bansil, Jing Li, Wen Chen ORCID, Xun Zhang, You-Lin Qiao
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Abstract Background In China, high-risk human papillomavirus (HR-HPV) prevalence is unexpectedly high in older women, but the possible reasons have not been well studied yet. This study investigated the age trends of HR-HPV infection in a prospective study. Methods A total of 7397 women aged 25-65 years without cervical precancer or cancer were evaluated during 2010-2011 with a stratified sample of 2791 women re-evaluated after one year. Test results for care HPV and care HPV16/18/45 were used to describe the HR-HPV prevalence, incidence and clearance. Risk factors associated with HR-HPV infections were explored using a logistic regression model. Results The overall HR-HPV prevalence was 13.1% at baseline, with a peak of 19.3% in women aged 55-59 years. The prevalence of HR-HPV (p for trends