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BioMed Central, BMC Infectious Diseases, 1(14), 2014

DOI: 10.1186/1471-2334-14-75

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Male circumcision and the incidence and clearance of genital human papillomavirus (HPV) infection in men: the HPV Infection in men (HIM) cohort study

Journal article published in 2014 by Ginesa Albero, F. Xavier Bosch, Xavier Castellsagué, Hui-Yi Lin, William Fulp, Luisa L. Villa, Eduardo Lazcano-Ponce ORCID, Mary Papenfuss, Martha Abrahamsen, Jorge Salmerón ORCID, Manuel Quiterio, Alan G. Nyitray, Beibei Lu, F. Xavier Bosch, Anna R. Giuliano
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Abstract Background Reported associations of male circumcision (MC) with human papillomavirus (HPV) infection in men have been inconsistent. Methods 4,033 healthy men were examined every six months for a median of 17.5 months. In each study visit, exfoliated cell specimens from the coronal sulcus/glans penis, penile shaft, and scrotum were collected and combined into one sample per person for HPV DNA detection. Samples were tested for 37 HPV types. Cox proportional hazards models were used to evaluate the association between MC and the incidence and clearance of HPV infections and specific genotypes. Results The overall incidence of new HPV infections did not differ by MC status (for any HPV, adjusted hazard ratio (aHR) 1.08, 95% confidence interval (CI) 0.91-1.27). However, incidence was significantly lower among circumcised versus uncircumcised men for HPV types 58 (p = 0.01), 68 (p