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BioMed Central, BMC Infectious Diseases, 1(14), 2014

DOI: 10.1186/1471-2334-14-131

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Focal bone lesions in hiv-positive patient treated with tenofovir

Journal article published in 2014 by Davide Mangioni ORCID, Alessandra Bandera ORCID, Antonio Muscatello, Nicola Squillace, Cinzia Crivellaro, Luca Guerra, Cristina Messa, Andrea Gori
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Abstract Background Tenofovir is a widely used antiviral drug for the treatment of HIV and HBV infection. Although its side effects on renal function and bone metabolism are well known, there are no reports on focal bone lesions caused by this drug. Our case suggests this new, unusual but important scenario. Case presentation We report on a 46-year-old HIV-positive man treated with an antiretroviral regimen containing tenofovir who suddenly developed localized inflammatory bone lesions. The examinations performed ruled out all the disorders commonly associated with this clinical pattern, and the patient’s conditions improved only after the suspension of tenofovir. Conclusions The case study suggests a rare but severe adverse event, which should be taken into account when physicians treat HIV-positive patients with focal inflammatory bone lesions