Esthesioneuroblastoma is a rare malignant tumor of the olfactory mucosa located in the sinonasal tract with a controversial management due to its low incidence and unknown origin.Craniofacial resection using a subfrontal approach is one of the techniques of choice for treating this complex entity. We describe a case treated in our institution that responded favorably to this procedure, as well as a thorough review of the literature regarding this type of tumor and the advantages of the approach.