Published in
Nature Research, Nature Genetics, 11(46), p. 1166-1169, 2014
DOI: 10.1038/ng.3096
Links
- ORCID
- ORCID
- ORCID
- Nature Research | PDF
- ORCID
- ORCID
- [www.researchgate.net] | PDF
- [www.researchgate.net] | PDF
- [iris.unito.it] | PDF
Tools
Hotspot activating PRKD1 somatic mutations in polymorphous low-grade adenocarcinomas of the salivary glands
Journal article published in 2014 by
Ilan Weinreb,
Salvatore Piscuoglio 
,
Luciano G. Martelotto ,
Daryl Waggott,
Charlotte Ky Y. Ng,
Bayardo Perez-Ordonez,
Nicholas J. Harding,
Javier Alfaro,
Kenneth C. Chu,
Agnes Viale,
Nicola Fusco ,
Arnaud da Cruz Paula,
Caterina Marchio,
Rita A. Sakr,
Raymond Lim
and other authors.
,
Luciano G. Martelotto ,
Daryl Waggott,
Charlotte Ky Y. Ng,
Bayardo Perez-Ordonez,
Nicholas J. Harding,
Javier Alfaro,
Kenneth C. Chu,
Agnes Viale,
Nicola Fusco ,
Arnaud da Cruz Paula,
Caterina Marchio,
Rita A. Sakr,
Raymond Lim
and other authors.
This paper is available in a repository.
Full text: Download
Published version:
archiving forbidden
Data provided by 
Abstract
Polymorphous low-grade adenocarcinoma (PLGA) is the second most frequent type of malignant tumor of the minor salivary glands. We identified PRKD1 hotspot mutations encoding p.Glu710Asp in 72.9% of PLGAs but not in other salivary gland tumors. Functional studies demonstrated that this kinase-activating alteration likely constitutes a driver of PLGA.