The purpose of this study was to examine the effects of graduated compression sleeves on muscle performance during high-intensity exercise. Twenty-four resistance trained men were randomly assigned to one of two groups: compression sleeve (GCS, n=11) or placebo sleeve (GPS, n=13). Participants performed 4 sets of 10 unilateral maximal eccentric/concentric elbow flexion repetitions on an isokinetic dynamometer at 120°s⁻¹ with 1 min of inter-set rest. Average torque, work and power were measured during concentric and eccentric actions. ANOVA revealed no significant interactions or main effects for group for any variable. However, values decreased significantly across sets for average torque (1^st = 46.55 ± 11.11 Nm to 4^th = 36.75 ± 8.78 Nm), average work (1^st = 78.83 ± 18.49 J to 4^th = 53.26 ± 10.04 J) and average power (1^st = 52.3 ± 12.03 W to 4^th = 32.59 ± 8.82 W). Therefore, the use of a graduated compression sleeve appears not enhance isokinetic elbow flexion muscle performance.