Österreichischer Apothekerverlag, Scientia Pharmaceutica, 3(74), p. 85-97
DOI: 10.3797/scipharm.2006.74.89
Österreichischer Apothekerverlag, Scientia Pharmaceutica, 3(74), p. 85-97
DOI: 10.3797/scipharm.2006.74.85
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A series of N-(2,4-difluorophenyl)-N’-heptyl-N’-{4-[(substituted)-pyridazin-3-yl)thio]pentyl}urea derivatives having a phenyl ring at positions 5 and/or at position 6 of the heterocycle, as well as the corresponding sulfones, were synthesized. Their inhibitory activity against acyl-CoA:cholesterol acyltransferase (ACAT) was tested on the enzyme prepared from rat liver microsomes. Theoretical studies were performed to correlate their activity to their structural features.