Published in

American Society for Clinical Investigation, Journal of Clinical Investigation, 5(115), p. 1111-1119, 2005

DOI: 10.1172/jci25102

American Society for Clinical Investigation, Journal of Clinical Investigation, 5(115), p. 1111-1119

DOI: 10.1172/jci200525102

Links

Tools

Export citation

Search in Google Scholar

Inflammation, stress, and diabetes

Journal article published in 2005 by Kathryn E. Wellen ORCID, Gökhan S. Hotamisligil
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Red circle
Preprint: archiving forbidden
Red circle
Postprint: archiving forbidden
Green circle
Published version: archiving allowed
Upload
Policy details
Data provided by SHERPA/RoMEO

Abstract

Over the last decade, an abundance of evidence has emerged demonstrating a close link between metabolism and immunity. It is now clear that obesity is associated with a state of chronic low-level inflammation. In this article, we discuss the molecular and cellular underpinnings of obesity-induced inflammation and the signaling pathways at the intersection of metabolism and inflammation that contribute to diabetes. We also consider mechanisms through which the inflammatory response may be initiated and discuss the reasons for the inflammatory response in obesity. We put forth for consideration some hypotheses regarding important unanswered questions in the field and suggest a model for the integration of inflammatory and metabolic pathways in metabolic disease.