The identification of an underground nuclear test from its seismic signal recorded by seismometers at regional distances is one of the fundamental scientific goals of the Comprehensive Test Ban Treaty R and D Program. The work being reported here addresses the issue of event discrimination through the use of computer models that use realistic simulations of nuclear explosions in various settings for the generation of near-regional and regional synthetic seismograms. The study exercises some unique, recently developed computer modeling capabilities that heretofore have not been available for discrimination studies. A variety of source conditions and regional paths are investigated. Under the assumptions of the study, conclusions are: (1) spall, non-linear deformation, and depth-of-burial do not substantially influence the near-regional signal and (2) effects due to basins along the regional path very much dominate over source region geology in influencing the signal at regional distances. These conclusions, however, are relevant only for the frequencies addressed, which span the range from 0.1 to 1 Hz for the regional calculations and 0.1 to 3 Hz for the near-regional calculations. They also are relevant only for the crudely ``China-like`` basin, crust, and mantle properties used in the study. If it is determined that further investigations are required, researchers may use this study as a template for such work.