Project Persevere examined teacher efficacy and burnout within Comprehensive, Integrated, Three-tiered (CI3T) models of prevention, as implemented in two middle schools in a southern state. Participating schools completed a year-long training series to design their CI3T plans and were in their first year of implementation as part of regular school practices. Participating teachers completed the Teachers’ Sense of Efficacy Scale 24-item Long Form (TSES; Tschannen-Moran & Woolfolk Hoy, 2001) and the Maslach Burnout Inventory (MBI; Maslach, Jackson, & Leiter, 1996) at the end of the school year. Teacher self-ratings were examined to describe how teachers in schools with prevention models were faring. Three sets of variables were examined: (a) teacher efficacy and burnout, (b) treatment integrity and social validity ratings of the CI3T model of prevention, and (c) student behavioral risk. Findings indicated both schools implemented the CI3T model with high integrity and teachers rated their plans with high social validity. Limitations and future directions are provided.