The aim of this study was to evaluate the possibility of using polyols derived from liquefied cork in the production of novel bio-based polyurethane foams (PUFs). For that propose, different liquefaction conditions were carry out at atmospheric pressure and moderate temperature where PEG and glycerol were used as solvents and sulfuric acid used as catalyst. The ensuing polyols were used to produce foams which were characterized by structural, morphological, thermal and mechanical analyses to demonstrate that liquefaction conditions play a crucial role on the properties of the ensuing foams. The resulting foams exhibited the typical cellular structure of PUFs with low densities (57.4 – 70.7 kg/m3) and low thermal conductivity (0.038-0.040 W/mk). However, the mechanical properties differed significantly depending on the liquefaction conditions. The best stress–strain results were obtained for the PUFs prepared using the polyol with lowest IOH and water content (Young modulus 475.0 kPa, compressive stress (σ10%) 34.6 kPa and toughness 7397.1 J/m3). This PUF was thermally stable up to 200 ºC and presented a glass transition temperature around 27 ºC. The results obtained demonstrated that these polyols from liquefied cork yield PUFs that are adequate materials for insulation applications.