Published in
Wiley, Angewandte Chemie, 21(126), p. 5470-5474
Wiley, Angewandte Chemie International Edition, 21(53), p. 5366-5370
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Dual-Pore Mesoporous Carbon@Silica Composite Core–Shell Nanospheres for Multidrug Delivery
,
Gengfeng Zheng,
Jianping Yang ,
Haosha Tang,
Yafeng Zhang,
Biao Kong,
Yingying Lv,
Congjian Xu,
Abdullah M. Asiri,
Jian Zi,
Fan Zhang,
Dongyuan Zhao
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Abstract
Monodispersed mesoporous phenolic polymer nanospheres with uniform diameters were prepared and used as the core for the further growth of core–shell mesoporous nanorattles. The hierarchical mesoporous nanospheres have a uniform diameter of 200 nm and dual-ordered mesopores of 3.1 and 5.8 nm. The hierarchical mesostructure and amphiphilicity of the hydrophobic carbon cores and hydrophilic silica shells lead to distinct benefits in multidrug combination therapy with cisplatin and paclitaxel for the treatment of human ovarian cancer, even drug-resistant strains.