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Elsevier, Molecular Metabolism, 7(4), p. 519-527, 2015

DOI: 10.1016/j.molmet.2015.04.002

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Fibroblast growth factor 21 is elevated in metabolically unhealthy obesity and affects lipid deposition, adipogenesis, and adipokine secretion of human abdominal subcutaneous adipocytes

Journal article published in 2015 by Lucia Berti, Martin Irmler, Marty Zdichavsky, Tobias Meile, Anja Böhm, Norbert Stefan, Andreas Fritsche, Johannes Beckers, Alfred Königsrainer, Hans-Ulrich Häring, Martin Hrabě de Angelis ORCID, Harald Staiger ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

•Metabolically healthy and unhealthy obese subjects differ in FGF21 blood levels.•FGF21 alters the secretome of human preadipocytes differentiated in vitro.•FGF21 exerts potent adiponectin-suppressive effects.•FGF21 and adiponectin may constitute a humoral vicious cycle between liver and fat.