Dissemin is shutting down on January 1st, 2025

Published in

Wiley-VCH Verlag, ChemInform, 41(44), p. no-no, 2013

DOI: 10.1002/chin.201341150

Elsevier, European Journal of Medicinal Chemistry, (63), p. 897-906

DOI: 10.1016/j.ejmech.2013.03.019

Links

Tools

Export citation

Search in Google Scholar

Synthesis of 1H-1,2,3-triazole linked β-lactam–isatin bi-functional hybrids and preliminary analysis of in vitro activity against the protozoal parasite Trichomonas vaginalis

Journal article published in 2013 by Raghu Raj, Pardeep Singh, Nathan T. Haberkern, Ryan M. Faucher, Neal Patel, Kirkwood M. Land, Vipan Kumar ORCID
This paper is available in a repository.
This paper is available in a repository.

Full text: Download

Red circle
Preprint: archiving forbidden
Orange circle
Postprint: archiving restricted
Upload
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

Twenty-two different triazoles were prepared to examine the anti-Trichomonas vaginalis structure-activity relationships (SAR) within the β-lactam-isatin-triazole conjugate family. The compounds were synthesized by copper-catalyzed 'click chemistry.'In vitro activity against T. vaginalis was determined at 10 and 100 μM for each compound, with eighteen of the synthesized hybrids showing 100% growth inhibition at 100 μM. The compound 5i, with no cytotoxicity on cultured CHO-K1 cells, is considered a good compound for further analysis.