Elsevier, Toxicon: An Interdisciplinary Journal on the Toxins Derived from Animals, Plants and Microorganisms, (93), p. 37-40, 2015
DOI: 10.1016/j.toxicon.2014.10.023
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In this work, an anti-loxoscelic serum was produced by immunizing horses with a recombinant dermonecrotic protein from Loxosceles intermedia (rLiD1). Anti-rLiD1 antibodies were able to recognize different species of Loxosceles venoms by Western Blot and ELISA. The efficacy of anti-rLiD1 serum against the toxic effects of Loxosceles laeta (Peru) venom was tested, showing that anti-rLiD1 serum can neutralize those effects. This study confirms that recombinant proteins can be good candidates to replace crude venoms for antivenom production.