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Taylor and Francis Group, Nucleosides, Nucleotides and Nucleic Acids, 8-9(26), p. 1145-1149

DOI: 10.1080/15257770701526978

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A Mini-Library of TBA Analogues Containing 3′-3′ and 5′-5′ Inversion of Polarity Sites

Journal article published in 2007 by V. Esposito, A. Galeone ORCID, L. Mayol ORCID, A. Randazzo, A. Virgilio, A. Virno
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This paper is available in a repository.

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Abstract

Several researches have been devoted to structure-activity relationship and to post-SELEX modifications of the thrombin binding aptamer (TBA), one of the first aptamers discovered by the SELEX methodology. However, no studies on TBA dealing with the effects of introduction of inversion of polarity sites have been reported yet. In this frame, we have undertaken the synthesis and the study of a mini-library composed of several TBA analogues containing a 3'-3' or a 5'-5' inversion of polarity site at different positions into the sequence. Particularly, in this article, we present preliminary results about their structural and biological properties.