Matrix macromolecules play pivotal roles in tissue properties, physiological processes, as well as the development and progression of several diseases. Proteoglycans (PGs), identified at both extracellular and cellular levels, are among the well-known matrix macromolecules implicated in all aspects of cell biology and human disease [1-3]. PGs may also act as receptors and/or co-receptors regulating cell signaling, growth factor-mediated signaling pathways and subsequently affecting cell functions. This article is protected by copyright. All rights reserved.