Synthesis and characterisation of macrocyclic diamino chiral crown ethers
Journal article published in 2004 by
Waldo H. Correa,
Janet L. Scott 
This paper is made freely available by the publisher.
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Abstract
A benign and efficient synthesis of chiral macrocyclic 'aza-crown' ethers of varying ring size is reported. The synthesis involves a Schiff base condensation of ether linked dialdehydes of varying chain length and (1R,2R)-(-)-1,2-diaminocyclohexane under mild conditions to yield the macrocycles, which are subsequently reduced to yield the diamino analogues.