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Elsevier, Cell Stem Cell, 6(10), p. 653-656, 2012

DOI: 10.1016/j.stem.2012.04.010

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Restoring Stem Cell Function in Aged Tissues by Direct Reprogramming?

Journal article published in 2012 by Natalia Tapia, Dong Wook Han, Hans R. Schöler
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Adult stem cells are responsible for the cellular turnover of many organs, and an impairment in their function leads to aging and disease. In efforts to reverse the process of tissue stem cell aging, we speculate on the promise and challenges of in vivo direct reprogramming strategies.