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Nature Research, Nature Chemical Biology, 10(6), p. 692-696, 2010

DOI: 10.1038/nchembio.441

Nature Research, Nature Chemical Biology, 11(6), p. 787-789, 2010

DOI: 10.1038/nchembio.462

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The challenges of integrating multi-omic data sets

Journal article published in 2010 by Bernhard Palsson, Karsten Zengler ORCID, Dan S. Tawfik
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Biological messiness relates to infidelity, heterogeneity, stochastic noise and variation--both genetic and phenotypic--at all levels, from single proteins to organisms. Messiness comes from the complexity and evolutionary history of biological systems and from the high cost of accuracy. For better or for worse, messiness is inherent to biology. It also provides the raw material for physiological and evolutionary adaptations to new challenges.