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Elsevier, EBioMedicine, 2-3(1), p. 173-180, 2014

DOI: 10.1016/j.ebiom.2014.10.014

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Imaging Inflammation in Asthma: Real Time, Differential Tracking of Human Neutrophil and Eosinophil Migration in Allergen Challenged, Atopic Asthmatics in Vivo

Journal article published in 2014 by Joanna J. Lukawska, Lefteris Livieratos, Barbara M. Sawyer, Tak Lee, Michael O'Doherty, Philip J. Blower, Martin Kofi, James R. Ballinger, Christopher J. Corrigan ORCID, Gopinath Gnanasegaran, Ehsan Sharif-Paghaleh, Gregory E. D. Mullen
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

•Isolation and radiolabelling of eosinophils or neutrophils from asthmatics significantly activates them.•Corticosteroids alter eosinophil, but not neutrophil 99mTc-HMPAO radiolabelling efficiency.•Leukocyte activation as a result of manipulation ex vivo does not measurably alter lung sequestration.•Eosinophil migration through the lungs of asthmatic patients is slower than in healthy volunteers.