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American Chemical Society, Journal of Natural Products, 2(75), p. 257-261, 2012

DOI: 10.1021/np2004165

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Antiproliferative Activity of trans-Avicennol from Zanthoxylum chiloperone var. angustifolium against Human Cancer Stem Cells

Journal article published in 2012 by Gerardo Cebrián-Torrejón, Antonieta Rojas de Arias, Suzana Assad Kahn, Suzana Assad Kahn, Nathalie Lagarde, Flavia Castellano, Karine Leblanc, Jordi Rodrigo, Valérie Molinier-Frenkel, Antonieta Rojas de Arias, Maria Elena Ferreira, Cécile Thirant ORCID, Alain Fournet, Bruno Figadère, Hervé Chneiweiss and other authors.
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Zanthoxylum chiloperone var. angustifolium root bark was studied with the aim of finding novel molecules able to overcome cancer stem cell chemoresistance. Purification of a methanol-soluble extract resulted in the isolation of a known pyranocoumarin, trans-avicennol (1). Compound 1 demonstrated antiproliferative activity on glioma-initiating cells, whereas it was inactive on human neural stem cells. trans-Avicennol (1) activated the MAPK/ERK pathway and was also evaluated for its ability to inhibit the enzyme indoleamine-2,3-dioxygenase.